Type 1 Diabetes
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Type 1 diabetes mellitus, commonly known as juvenile diabetes or insulin-dependent diabetes, is an autoimmune disorder that attacks and destroys insulin-producing islet cells in the pancreas, resulting in glucose accumulation in the blood. Those suffering from type 1 diabetes must take insulin to regulate blood sugar levels. Over time, poorly controlled diabetes can lead to serious health conditions, including heart disease, stroke, blindness, amputations, kidney disease and nerve damage. Currently, there are no preventive measures for type 1 diabetes.
Pre-clinical studies first conducted by researchers at Genzyme found that MSCs may have the ability to delay the progression of type 1 diabetes by preserving beta cell function.
Allogeneic MSCs protect islet cells from rejection and inhibit T-cell infiltration allowing for continued insulin production.